NAD+ Shield
NAD+ Shield
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Gluten-free
Dairy-free
Soy-free
Non-GMO
Promotes the body’s normal cellular repair and maintenance process.*
NAD+ Shield is uniquely formulated to support the body’s normal cellular repair process, antioxidative status, and healthy aging.*
This formula contains clinically relevant amounts of Niagen® (a form of nicotinamide riboside chloride [NR]), resveratrol (as Veri‑te™), and pterostilbene.
NR is a variation of vitamin B3 (niacin), and it is a building block to nicotinamide adenine dinucleotide (NAD+).
NAD+ is found in every living cell and is essential to many important cellular processes. NAD+ plays a role in more than 500 reactions in the body, including gene expression, stress response, and the body’s normal DNA repair process.*
Resveratrol is a bioactive plant compound found in grape skin and berries (such as blueberries and raspberries) and is also found in peanuts.
Resveratrol is known for its role in supporting a healthy response to oxidative stress and a normal inflammatory response.* Research suggests that resveratrol may also support the body’s normal processes of cellular regeneration and repair.*
Pterostilbene is another plant‑derived compound that is structurally similar to resveratrol. This highly bioavailable molecule has been shown to support antioxidant status, a healthy inflammatory response, and healthy cellular function.*
Together, the nutrients within NAD+ Shield help to support a healthy cell cycle, the body’s normal cellular repair process, and a healthy response to oxidative stress, along with healthy aging.*
Recommended Use: Take 2 capsules per day with a meal or as directed by your health-care practitioner.
References:
1. Airhart SE, Shireman LM, Risler LJ, et al. An open‑label, non‑randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One. 2017;12(12):e0186459. doi:10.1371/journal.pone.0186459.
2. Mehmel M, Jovanović N, Spitz U. Nicotinamide riboside‑the current state of research and therapeutic uses. Nutrients. 2020;12(6):1616. doi:10.3390/nu12061616.
3. Nakagawa T, Guarente L. Sirtuins at a glance. J Cell Sci. 2011;124(pt 6):833‑838. doi:10.1242/jcs.081067.
4. Braidy N, Berg J, Clement J, et al. Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age‑related degenerative diseases: Rationale, biochemistry, pharmacokinetics, and outcomes. Antioxid Redox Signal. 2019;30(2):251‑294. doi:10.1089/ars.2017.7269.
5. Yamamoto H, Schoonjans K, Auwerx J. Sirtuin functions in health and disease. Mol Endocrinol. 2007;21(8):1745‑1755. doi:10.1210/me.2007‑0079.
6. Gomes AP, Price NL, Ling AJ, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear‑mitochondrial communication during aging. Cell. 2013;155(7):1624‑1638. doi:10.1016/j.cell.2013.11.037.
7. Satoh A, Brace CS, Rensing N, et al. Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. Cell Metab. 2013;18(3):416‑430. doi:10.1016/j.cmet.2013.07.013.
8. Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. Age‑associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One. 2012;7(7):e42357. doi:10.1371/journal.pone.0042357.
9. Zhu XH, Lu M, Lee BY, Ugurbil K, Chen W. In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A. 2015;112(9):2876‑2881. doi:
10.1073/pnas.1417921112. 10. Okabe K, Yaku K, Tobe K, Nakagawa T. Implications of altered NAD metabolism in metabolic disorders. J Biomed Sci. 2019;26(1):34. doi:10.1186/s12929‑019‑0527‑8.
11. Wu J, Jin Z, Zheng H, Yan LJ. Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications. Diabetes Metab Syndr Obes. 2016;9:145‑53. doi:10.2147/DMSO.S106087.
12. Lautrup S, Sinclair DA, Mattson MP, Fang EF. NAD+ in brain aging and neurodegenerative disorders. Cell Metab. 2019;30(4):630‑655. doi:10.1016/j.cmet.2019.09.001.
13. Zhang M, Ying W. NAD+ deficiency is a common central pathological factor of a number of diseases and aging: mechanisms and therapeutic implications. Antioxid Redox Signal. 2019;30(6):890‑905. doi:10.1089/ars.2017.7445.
14. Yoshino J, Baur JA, Imai SI. NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metab. 2018;27(3):513‑528. doi:10.1016/j.cmet.2017.11.002.
15. Conze D, Brenner C, Kruger CL. Safety and metabolism of long‑term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double‑blind, placebo‑controlled clinical trial of healthy overweight adults. Sci Rep. 2019;9(1):9772. doi:10.1038/s41598‑019‑46120‑z.
16. Liu RM. Aging, cellular senescence, and Alzheimer’s disease. Int J Mol Sci. 2022;23(4):1989. doi:10.3390/ijms23041989.
17. Hou Y, Wei Y, Lautrup S, et al. NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS‑STING. Proc Natl Acad Sci U S A. 2021;118(37):e2011226118. doi:10.1073/pnas.2011226118.
18. Bottani E, Lamperti C, Prigione A, Tiranti V, Persico N, Brunetti D. Therapeutic approaches to treat mitochondrial diseases: “one‑size‑fits‑all” and “precision medicine” strategies. Pharmaceutics. 2020;12(11):1083. doi:10.3390/pharmaceutics12111083
19. She J, Sheng R, Qin ZH. Pharmacology and potential implications of nicotinamide adenine dinucleotide precursors. Aging Dis. 2021;12(8):1879‑1897. doi:10.14336/AD.2021.0523.
20. Elhassan YS, Kluckova K, Fletcher RS, et al. Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti‑inflammatory signatures. Cell Rep. 2019;28(7):1717‑1728.e6. doi:10.1016/j.celrep.2019.07.043.
Ingredients
Serving Size: 2 capsules
Servings Per Container: 30
- Nicotinamide Riboside Chloride (NIAGEN®) – 300 mg *
- Trans Resveratrol (Veri-te™) – 200 mg *
- Trans-Pterostilbene – 50 mg *
* Daily Value not established.
Other Ingredients: Cellulose (capsule), microcrystalline cellulose, dicalcium phosphate, vegetable stearate, quillaja extract.
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There are a couple of rare exceptions where products contain trace amounts of egg and a few contain tree nuts. All ingredients are clearly indicated on the product pages. Be sure to read carefully if you have any known food allergies or sensitivities.
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