Methyl B12 + Folate
Methyl B12 + Folate
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Gluten-free
Dairy-free
Soy-free
Non-GMO
Vitamin B12 works along with folate in many body processes. These include increasing metabolic energy and red blood cell production, supporting mood regulation and cognitive function, up-regulating methylation, increasing DNA synthesis and repair, and supporting the formation of the protective myelin sheath, the insulating exterior that speeds up nerve cell transmission.
Most B12 supplements contain cyanocobalamin. In order for B12 to be utilized in the body, the liver must first remove the cyanide molecule and attach a methyl group to form methylcobalamin, the biologically active, tissue-ready form. Research has shown that methylcobalamin is more efficiently used and retained in the body than the cyanocobalamin form.
Adding significant synergy to this formula is the methylated form of folic acid, 5-methyltetrahydrofolate (5-MTHF). 5-MTHF activates B12 in the body by donating its methyl group to cobalamin, forming methylcobalamin. 5-MTHF requires the enzyme 5-methylenetetrahydrofolate reductase (5-MTHFR) in order to be converted from folic acid into its active form, 5-MTHF.
Enzyme defects, malabsorption, and congenital deficiency of 5-MTHFR can result in an impaired ability to activate folic acid. In individuals with a genetic defect of this enzyme, supplementation with 5-MTHF may be the preferable form of folate supplementation.
Energy Support
Vitamin B12 plays a large role as a cofactor in enzymes involved in the metabolism of proteins, fats, and carbohydrates, and is required to produce succinyl CoA, an intermediary in the Kreb's cycle that generates cellular energy in the form of adenosine triphosphate (ATP). Due to its role in the production of ATP, vitamin B12 deficiency is often characterized by fatigue and weakness. Supplementation with methylcobalamin and 5-MTHF has been shown to promote increased energy levels.
Peripheral Circulation and Nerve Cell Health
In a double-blind study, oral administration of methylcobalamin (500 mcg three times daily for four months) showed a significant improvement in neuromuscular health. The subjects in the control group reported improvement in muscle aches, fatigue, sensitivity to pain, circulation, muscle cramps and reflexes.
Cardiovascular Health and Homocysteine Balance
Homocysteine is a molecule which is synthesized in the body from the amino acid methionine. Maintaining healthy homocysteine balance is crucial for supporting arterial and cardiovascular health. Both 5-MTHF and methylcobalamin are required to maintain optimal homocysteine balance. 5-MTHF acts as a methyl donor, providing a methyl group to vitamin B12. The methylated form of B12 (methylcobalamin) then transfers the methyl group to homocysteine, resulting in consistent recycling of homocysteine to methionine.
Mental and Cognitive Health
B12 has been shown to be beneficial for maintaining a positive mental outlook because it acts as a methyl donor and increases the synthesis of s-adenosylmethionine (SAM-e), a nutrient that has powerful mood and sleep-cycle regulating properties. Due to B12’s ability to increase the production of neurotransmitters and nerve cell transmission, B12 has been shown to improve cognitive function. 5-MTHF plays a significant role in mood regulation as it is required as a methyl group donor for the production of neurotransmitters such as serotonin.
Sleep Cycle Regulation
Methylcobalamin and 5-MTHF are both required nutrients for the biosynthesis of melatonin, the hormone that helps induce sleep. Within the central nervous system, the neurotransmitter serotonin is converted into melatonin in a pathway that requires the donation of a methyl group.
Each tablet provides 5,000 mcg of methylcobalamin and 1,000 mcg of folate as Quatrefolic® (100% 5-MTHF).
Ingredients
Supplement Facts
Serving Size 1 Tablet
Servings Per Container 60
|
Amount Per Serving |
% Daily Value |
|
|---|---|---|
| Folate | 1,700 mcg DFE | 425% |
|
(from 1,000 mcg as Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt) |
||
| Vitamin B12 | 5,000 mcg | 208,333% |
| (as Methylcobalamin) | ||
Other Ingredients: Isomalt, Natural Cane Sugar, Croscarmellose Sodium, Potassium Bicarbonate, Natural Cherry Flavor (msg free), Sodium Stearyl Fumarate, Stearic Acid, Citric Acid, Silicon Dioxide and Bilberry Fruit Extract.
Distributed by: Every Life Well®
6836 Bee Cave Rd., Suite 114
Austin, Texas 78746
Report any adverse reactions to 512-732-9975 or
store@everylifewell.com
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What makes my supplements different?
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There are a couple of rare exceptions where products contain trace amounts of egg and a few contain tree nuts. All ingredients are clearly indicated on the product pages. Be sure to read carefully if you have any known food allergies or sensitivities.
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