Dr. Shippy Approved
5-MTHF is the most biologically active form of the water-soluble B vitamin, folate.
It is the preferred form of folate supplementation due to an array of conditions that can limit conversion or absorption of folic acid.
Along with vitamin B12, folate serves as a donor of methyl groups.
The body utilizes methyl groups in many nervous system and metabolic processes, including the conversion of homocysteine to methionine, the synthesis of monoamine neurotransmitters, the production of melatonin, and the synthesis of DNA.
Data indicate that supplementing with 5-MTHF increases plasma folate more effectively than folic acid.
In addition, sufficient folate is necessary for brain and nervous system functions and for a healthy pregnancy outcome.*
5-MTHF—Preferred Over Folic Acid.
Folic acid is the synthetic form of folate that is used to fortify foods. It is often found in dietary supplements as well.
Despite some research showing that folic acid and 5-MTHF have equivalent bioavailability, 5-MTHF is often the preferred form to replenish folate. This is due, primarily, to the presence of digestive or metabolic variabilities that can affect the conversion of folic acid to 5-MTHF.
Furthermore, studies have shown that 5-MTHF increased plasma folate more effectively than folic acid irrespective of genetic differences in metabolism.
A study in women of childbearing age showed that 5-MTHF was more effective than folic acid in improving overall folate status.*
Using 5-MTHF instead of folic acid has several important advantages.
5-MTHF provides the biologically active form of folate, reduces the potential for masking hematological symptoms of vitamin B12 deficiency, reduces interactions with drugs that inhibit dihydrofolate reductase, overcomes folate metabolism challenges associated with functioning of methylenetetrahydrofolate reductase (MTHFR), and prevents the potential negative effects of UMFA in the peripheral circulation.*