{"product_id":"methyl-b12-folate","title":"Methyl B12 + Folate","description":"\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003cstrong\u003eVitamin B12 \u003c\/strong\u003eworks along with folate in many body processes. These include increasing metabolic energy and red blood cell production, supporting mood regulation and cognitive function, up-regulating methylation, increasing DNA synthesis and repair, and supporting the formation of the protective myelin sheath, the insulating exterior that speeds up nerve cell transmission. \u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eMost B12 supplements contain cyanocobalamin. In order for B12 to be utilized in the body, the liver must first remove the cyanide molecule and attach a methyl group to form methylcobalamin, the biologically active, tissue-ready form. Research has shown that methylcobalamin is more efficiently used and retained in the body than the cyanocobalamin form. \u003c\/span\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003e\u003cstrong\u003eAdding significant synergy to this formula is the methylated form of folic acid, 5-methyltetrahydrofolate (5-MTHF).\u003c\/strong\u003e 5-MTHF activates B12 in the body by donating its methyl group to cobalamin, forming methylcobalamin. 5-MTHF requires the enzyme 5-methylenetetrahydrofolate reductase (5-MTHFR) in order to be converted from folic acid into its active form, 5-MTHF. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp dir=\"ltr\"\u003e\u003cspan\u003eEnzyme defects, malabsorption, and congenital deficiency of 5-MTHFR can result in an impaired ability to activate folic acid. In individuals with a genetic defect of this enzyme, supplementation with 5-MTHF may be the preferable form of folate supplementation. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eEnergy Support\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eVitamin B\u003csub\u003e12\u003c\/sub\u003e plays a large role as a cofactor in enzymes involved in the metabolism of proteins, fats, and carbohydrates, and is required to produce succinyl CoA, an intermediary in the Kreb's cycle that generates cellular energy in the form of adenosine triphosphate (ATP). Due to its role in the production of ATP, vitamin B\u003csub\u003e12\u003c\/sub\u003e deficiency is often characterized by fatigue and weakness. Supplementation with methylcobalamin and 5-MTHF has been shown to promote increased energy levels.\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003ePeripheral Circulation and Nerve Cell Health\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eIn a double-blind study, oral administration of methylcobalamin (500 mcg three times daily for four months) showed a significant improvement in neuromuscular health. The subjects in the control group reported improvement in muscle aches, fatigue, sensitivity to pain, circulation, muscle cramps and reflexes.\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eCardiovascular Health and Homocysteine Balance\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eHomocysteine is a molecule which is synthesized in the body from the amino acid methionine. Maintaining healthy homocysteine balance is crucial for supporting arterial and cardiovascular health. Both 5-MTHF and methylcobalamin are required to maintain optimal homocysteine balance. 5-MTHF acts as a methyl donor, providing a methyl group to vitamin B\u003csub\u003e12\u003c\/sub\u003e. The methylated form of B\u003csub\u003e12\u003c\/sub\u003e (methylcobalamin) then transfers the methyl group to homocysteine, resulting in consistent recycling of homocysteine to methionine.\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eMental and Cognitive Health\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eB\u003csub\u003e12\u003c\/sub\u003e has been shown to be beneficial for maintaining a positive mental outlook because it acts as a methyl donor and increases the synthesis of s-adenosylmethionine (SAM-e), a nutrient that has powerful mood and sleep-cycle regulating properties. Due to B\u003csub\u003e12\u003c\/sub\u003e’s ability to increase the production of neurotransmitters and nerve cell transmission, B\u003csub\u003e12\u003c\/sub\u003e has been shown to improve cognitive function. 5-MTHF plays a significant role in mood regulation as it is required as a methyl group donor for the production of neurotransmitters such as serotonin.\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eSleep Cycle Regulation\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003eMethylcobalamin and 5-MTHF are both required nutrients for the biosynthesis of melatonin, the hormone that helps induce sleep. Within the central nervous system, the neurotransmitter serotonin is converted into melatonin in a pathway that requires the donation of a methyl group.\u003c\/p\u003e\n\u003cp\u003eEach tablet provides 5,000 mcg of methylcobalamin and 1,000 mcg of folate as Quatrefolic® (100% 5-MTHF).\u003c\/p\u003e","brand":"annshippymd","offers":[{"title":"Default Title","offer_id":50513134518509,"sku":"OMMEB1260","price":33.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0468\/0869\/4952\/files\/103ab1a6-edf3-4e94-a924-2c75537da38b.png?v=1787261716","url":"https:\/\/shop.annshippymd.com\/products\/methyl-b12-folate","provider":"annshippymd","version":"1.0","type":"link"}